关键词: KM 小鼠, 软饮料, 生长发育, 血清生化, 脏器系数, 组织切片

Abstract: Objective In order to study the effects of drinking soft drinks for a long period of time on the growth, serum biochemical indexes and tissue cells of mice. Method 80 healthy Kunming mice ( half male and half female) were divided into 5 groups, which were free to drink Mirinda, Cola, green tea, coffee and boiled water ( control group) respectively. The other experimental conditions were the same. The body weight, average daily feed intake, serum biochemical indexes, organ coefficient and tissue microscopic changes of mice in different groups were compared. Result The body weights of female mice who drank 4 kinds of soft drinks were higher than the boiled water group in each period. The weights of male mice were significantly higher than the boiled water group (P<0. 05) during 0-50 days, while decreasing during 50-66 days. Serum biochemical indexes indicate that long-term drinking of soft drinks can increase the level of triglyceride in mice (P<0. 05) ; have no significant effect on the organ coefficients of mice (P>0. 05) , but they can cause different levels of degeneration of liver cells and cause protein casts in renal tubules. Conclusion Long-term drinking of soft drinks has a certain effect on the growth and development of mice, and also has certain adverse effects on fat metabolism, liver and kidney function.

Key words: Kunming mice, soft drinks, growth and development, serum biochemical indexes, viscera coefficient, tissue microscopic changes